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PPARD Antibody (C-term)

PPARD Antibody (C-term)

Item no.	ABC-AP11939b
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PPAR-delta, PPARD, NR1C2, PPARB, Peroxisome proliferator-activated receptor delta, NUCI, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, NUC1
Available
Primary Accession	Q03181
Antigen Type	Synthetic Peptide
Application	FC, WB
Bio Background	This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
Bio References	Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Christopoulos, P., et al. Ann. N. Y. Acad. Sci. 1205, 185-191 (2010) : Dunn, S.E., et al. J. Exp. Med. 207(8):1599-1608(2010) Eynon, N., et al. Mitochondrion (2010) In press : Jguirim-Souissi, I., et al. Genet. Mol. Res. 9(3):1326-1333(2010)
Clonality	Polyclonal
Clone/Animal Names	RB31677
Gene ID	5467
Gene Name	PPARD
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	PPARD Antibody (C-term) (Cat. #AP11939b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PPARD antibody detected the PPARD protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	PPARD Antibody (C-term) (Cat. #AP11939b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 2	FC
Dilution image 2	1:10~50
Other Accession	NP_803184.1
Isotype	Rabbit Ig
Calculated MW	49903
Antigen Region	367-394
Antigen Source	HUMAN
Target/Specificity	This PPARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-394 amino acids from the C-terminal region of human PPARD.
NCBI Accession	NP_001165289.1; NP_001165290.1; NP_001165291.1; NP_006229.1; NP_803184.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 9/6/2024

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