Manufacturer |
Abcepta
|
Category |
|
Type |
Antibody Primary |
Specific against |
other |
Isotype |
Ig |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB, IF, IHC-P |
Amount |
400 ul |
Host |
Rabbit |
Item no. |
ABC-AP11874c |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Primary Accession |
P03956 |
Antigen Type |
Synthetic Peptide |
Application |
IF, IHC-P, WB |
Bio Background |
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. This gene encodes a secreted enzymewhich breaks down the interstitial collagens, types I, II, and III.The gene is part of a cluster of MMP genes which localize tochromosome 11q22.3. Alternative splicing results in multipletranscript variants. |
Bio References |
Beshir, A.B., et al. Cancer Lett. 299(2):137-149(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Malik, N., et al. J. Neurooncol. (2010) In press :Skorupski, P., et al. Ginekol. Pol. 81(8):594-599(2010)Mossbock, G., et al. Mol. Vis. 16, 1764-1770 (2010) : |
Clonality |
Polyclonal |
Clone/Animal Names |
RB18908 |
Gene ID |
4312 |
Gene Name |
MMP1 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Confocal immunofluorescent analysis of MMP1 Antibody (Center) (Cat#AP11874c) with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). |
Type image 1 |
IF |
Dilution image 1 |
1:10~50 |
Legend image 2 |
MMP1 Antibody (Center) (Cat. #AP11874c) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the MMP1 antibody detected the MMP1 protein (arrow). |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Legend image 3 |
MMP1 Antibody (Center) (Cat. #AP11874c)immunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MMP1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. |
Type image 3 |
IHC-P |
Dilution image 3 |
1:50~100 |
Other Accession |
NP_002412 |
Isotype |
Rabbit Ig |
Calculated MW |
54007 |
Antigen Region |
317-347 |
Antigen Source |
HUMAN |
Target/Specificity |
This MMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-347 amino acids from the Central region of human MMP1. |
NCBI Accession |
NP_002412.1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.