Item no. |
ABC-AP11459b-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB, FC |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
CPT1C, CATL1, Carnitine O-palmitoyltransferase 1, brain isoform, CPT IC, Carnitine O-palmitoyltransferase I, brain isoform, Carnitine palmitoyltransferase 1C, CPT1-B, CPTI-B |
Available |
|
Primary Accession |
Q8TCG5 |
Antigen Type |
Synthetic Peptide |
Application |
WB, FC |
Bio Background |
The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine. |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Roomets, E., et al. Invest. Ophthalmol. Vis. Sci. 49(4):1660-1664(2008)Sierra, A.Y., et al. J. Biol. Chem. 283(11):6878-6885(2008)Price, N., et al. Genomics 80(4):433-442(2002) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB19024 |
Gene ID |
126129 |
Gene Name |
CPT1C |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
CPT1C Antibody (C-term) (Cat. #AP11459b) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CPT1C antibody detected the CPT1C protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
CPT1C Antibody (C-term) (Cat. #AP11459b) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Type image 2 |
FC |
Dilution image 2 |
1:10~50 |
Other Accession |
NP_001129524.1; NP_689572.1 |
Isotype |
Rabbit Ig |
Calculated MW |
90989 |
Antigen Region |
752-782 |
Antigen Source |
HUMAN |
Target/Specificity |
This CPT1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 752-782 amino acids from the C-terminal region of human CPT1C. |
NCBI Accession |
NP_001129524.1; NP_001186681.1; NP_001186682.1; NP_689572.1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.