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COP1 Antibody (N-term)

COP1 Antibody (N-term)

Item no.	ABC-AP11328a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Neural Signaling Antibodies Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Cell Status Apoptosis Flow Cytometry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot, Flow cytometry
Clone	1583CT111.17.7.37
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Caspase recruitment domain-containing protein 16, Caspase recruitment domain-only protein 1, CARD-only protein 1, Caspase-1 inhibitor COP, Pseudo interleukin-1 beta converting enzyme, Pseudo-ICE, Pseudo-IL1B-converting enzyme, CARD16, COP, COP1
Available
Primary Accession	Q5EG05
Other Accession	P29466; NP_443121.1; NP_001017534.1
Antigen Type	Synthetic Peptide
Bio Background	Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
Bio References	Bailey, S.D., et al. Diabetes Care (2010) In press : Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Wang, X., et al. Biochim. Biophys. Acta 1762(8):742-754(2006) Wang, X., et al. J. Neurosci. 25(50):11645-11654(2005) Lamkanfi, M., et al. J. Biol. Chem. 279(50):51729-51738(2004)
Gene ID	114769
Gene Name	CARD16
Reactivity	H
Calculated MW	22625
Antigen Region	37-65
Antigen Source	HUMAN
Target/Specificity	This COP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COP1.
NCBI Accession	NP_001017534.1; NP_443121.1

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Amount: 80 ul

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