TIMP1 Antibody (C-term)

NP_003245

This gene belongs to the TIMP gene family. The proteins
encoded by this gene family are natural inhibitors of the matrix
metalloproteinases (MMPs), a group of peptidases involved in
degradation of the extracellular matrix. In addition to its
inhibitory role against most of the known MMPs, the encoded protein
is able to promote cell proliferation in a wide range of cell
types, and may also have an anti-apoptotic function. Transcription
of this gene is highly inducible in response to many cytokines and
hormones. In addition, the expression from some but not all
inactive X chromosomes suggests that this gene inactivation is
polymorphic in human females. This gene is located within intron 6
of the synapsin I gene and is transcribed in the opposite
direction.

7076

H

157-188

This TIMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-188 amino acids from the C-terminal region of human TIMP1.