Item no. |
ABC-AP11126a-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB, FC, IF, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
INHBA, Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF |
Available |
|
Primary Accession |
P08476 |
Antigen Type |
Synthetic Peptide |
Application |
WB, IHC-P, IF, FC |
Bio Background |
The inhibin beta A subunit joins the alpha subunit to forma pituitary FSH secretion inhibitor. Inhibin has been shown toregulate gonadal stromal cell proliferation negatively and to havetumor-suppressor activity. In addition, serum levels of inhibinhave been shown to reflect the size of granulosa-cell tumors andcan therefore be used as a marker for primary as well as recurrentdisease. Because expression in gonadal and various extragonadaltissues may vary severalfold in a tissue-specific fashion, it isproposed that inhibin may be both a growth/differentiation factorand a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form aheterodimer, activin AB, both of which stimulate FSH secretion.Finally, it has been shown that the beta A subunit mRNA isidentical to the erythroid differentiation factor subunit mRNA andthat only one gene for this mRNA exists in the human genome. |
Bio References |
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :Lascorz, J., et al. Carcinogenesis 31(9):1612-1619(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) : |
Clonality |
Polyclonal |
Clone/Animal Names |
RB20703 |
Gene ID |
3624 |
Gene Name |
INHBA |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Confocal immunofluorescent analysis of INHBA Antibody (N-term)(Cat#AP11126a) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). |
Type image 1 |
IF |
Dilution image 1 |
1:10~50 |
Legend image 2 |
INHBA Antibody (N-term) (Cat. #AP11126a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the INHBA antibody detected the INHBA protein (arrow). |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Legend image 3 |
INHBA Antibody (N-term) (Cat. #AP11126a)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of INHBA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Type image 3 |
IHC-P |
Dilution image 3 |
1:10~50 |
Legend image 4 |
INHBA Antibody (N-term) (Cat. #AP11126a) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Type image 4 |
FC |
Dilution image 4 |
1:10~50 |
Other Accession |
P18331; Q04998; P07995; NP_002183.1; P55102; P43032 |
Predicted |
B, Hs, M, Rat, Sh |
Isotype |
Rabbit Ig |
Calculated MW |
47442 |
Antigen Region |
85-112 |
Antigen Source |
HUMAN |
Target/Specificity |
This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the N-terminal region of human INHBA. |
NCBI Accession |
NP_002183.1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.