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GAD2 Antibody (Center)

GAD2 Antibody (Center)

Item no.	ABC-AP11118C-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Neuroscience Neuroinflammation Molecular Targets for Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Type	Antibody Polyclonal
Applications	Immunofluorescence, Western Blot, Immunohistochemistry
Clone	RB53573
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase 65 kDa isoform, GAD2, GAD65
Available
Primary Accession	Q05329
Other Accession	Q05683; P48321; P48320; NP_001127838.1; NP_000809.1
Antigen Type	Synthetic Peptide
Bio Background	This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Bio References	Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) : Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) : Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Gene ID	2572
Gene Name	GAD2
Reactivity	H
Predicted	M, Pig, Rat
Calculated MW	65411
Antigen Region	109-138
Antigen Source	HUMAN
Target/Specificity	This GAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human GAD2.
NCBI Accession	NP_000809.1; NP_001127838.1

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Amount: 80 ul

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