Bio Background |
PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]). |
Bio References |
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Thean, L.F., et al. Genes Chromosomes Cancer 49(2):99-106(2010) Trynka, G., et al. Gut 58(8):1078-1083(2009) Saito, S., et al. J. Biol. Chem. 283(10):6584-6593(2008) Saito, J., et al. Biochem. J. 405(3):591-596(2007) |