Bio Background |
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Gartlan, K.H., et al. J. Immunol. 185(6):3158-3166(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Zhao, X., et al. Blood 110(7):2569-2577(2007) Meyer-Wentrup, F., et al. J. Immunol. 178(1):154-162(2007) |