Item no. |
ABC-AP10190a-ev-80ul |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
Western Blot, Flow cytometry |
Clone |
RB51538 |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Polypeptide N-acetylgalactosaminyltransferase 4, Polypeptide GalNAc transferase 4, GalNAc-T4, pp-GaNTase 4, Protein-UDP acetylgalactosaminyltransferase 4, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4, GALNT4 |
Available |
|
Primary Accession |
Q8N4A0 |
Other Accession |
O08832; NP_003765.2 |
Antigen Type |
Synthetic Peptide |
Bio Background |
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. |
Bio References |
O'Halloran, A.M., et al. J. Thromb. Thrombolysis 27(2):175-184(2009) Argueso, P., et al. Invest. Ophthalmol. Vis. Sci. 44(1):86-92(2003) Hassan, H., et al. J. Biol. Chem. 275(49):38197-38205(2000) Bennett, E.P., et al. J. Biol. Chem. 273(46):30472-30481(1998) Bennett, E.P., et al. Glycobiology 8(6):547-555(1998) |
Gene ID |
100528030; 8693 |
Gene Name |
GALNT4 |
Reactivity |
H |
Predicted |
M |
Calculated MW |
66666 |
Antigen Region |
93-120 |
Antigen Source |
HUMAN |
Target/Specificity |
This GALNT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the N-terminal region of human GALNT4. |
NCBI Accession |
NP_001186711.1; NP_003765.2 |
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