Item no. |
ABC-AO1306a |
Manufacturer |
Abcepta
|
Amount |
100 ul |
Category |
|
Type |
Antibody Primary |
Applications |
IHC, ELISA |
Clone |
1D7 |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
NT5E, NTE, NT5, 5'-nucleotidase, Ecto-5'-nucleotidase, CD73, 5'-NT, 3.1.3.5 |
Available |
|
Primary Accession |
P21589 |
Antigen Type |
Recombinant Protein |
Application |
IHC, E |
Bio References |
1. Oncol Rep. 2007 Jun; 17(6):1341-6. 2. Neurochem Int. 2003 Dec; 43(7):621-8. |
Clonality |
Monoclonal |
Gene ID |
4907 |
Gene Name |
NT5E |
Subtitle |
Purified Mouse Monoclonal Antibody |
Reactivity |
H |
Legend image 1 |
Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), cholangiocarcinorna (B), lymph node (C) and esophagus (D) tissues using NT5E mouse mAb with DAB staining. |
Type image 1 |
IHC |
Dilution image 1 |
1/200 - 1/1000 |
Legend image 2 |
Figure 1: Western blot analysis using FRK mouse mAb against K562 cell lysate (1). |
Type image 2 |
WB |
Dilution image 2 |
1:500~~2000 |
Isotype |
IgG1 |
Calculated MW |
63368 |
Formulation |
Ascitic fluid containing 0.03% sodium azide. |
Description |
5'-nucleotidase, ecto (NT5E), also known as CD73 (Cluster of Differentiation 73). Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. |
|
Clone: 1D7 |
Immunogen |
Purified recombinant fragment of NT5E expressed in E. Coli. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.