Ki67 Antibody

Recombinant Protein

1. Folia Histochem Cytobiol. 2007; 45(4):357-66. 2. Tumori. 2008 May-Jun; 94(3):389-97.

4288

Purified Mouse Monoclonal Antibody

Figure 1: Western blot analysis using Ki67 mouse mAb against truncated Trx-Ki67 recombinant protein(1), truncated Ki67 (aa3118-3256)-His recombinant protein(2) and truncated Ki67 (aa3118-3256)-hIgGFc transfected CHO-K1 cell lysate(3).

1/500 - 1/2000

358694

Ki67: antigen identified by monoclonal antibody Ki-67. Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.

Purified recombinant fragment of Ki167 (aa3118-3256) expressed in E. Coli.