Item no. |
ABC-AO1137a |
Manufacturer |
Abcepta
|
Amount |
100 ul |
Category |
|
Type |
Antibody Primary |
Applications |
WB, ELISA |
Clone |
7D7B11 |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
SORL1, SorLA, C11orf32, LR11, SorLA-1, LDLR relative with 11 ligand-binding repeats, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, Sortilin-related receptor, Sorting protein-related receptor containing LDLR class A repeats |
Available |
|
Primary Accession |
Q92673 |
Antigen Type |
Recombinant Protein |
Application |
WB, E |
Bio References |
1. Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61(8):1200-5. 2. Gabrielsson BG. Olofsson LE. Sjogren A. et al. Obes Res. 2005, Apr, 13(4):649-52. 3. Shah S. Yu G. Mol Interv. 2006, Apr, 6(2):74-6, 58. Review. |
Clonality |
Monoclonal |
Gene ID |
6653 |
Gene Name |
SORL1 |
Subtitle |
Purified Mouse Monoclonal Antibody |
Reactivity |
H |
Legend image 1 |
Figure 1: Western blot analysis using SORL1 mouse mAb against truncated SORL1 recombinant protein (1) and SORL1 (aa2159-2214)-hIgGFc transfected CHO-K1 cell lysate (2). |
Type image 1 |
WB |
Dilution image 1 |
1/500 - 1/2000 |
Legend image 2 |
Figure 2: Immunohistochemical analysis of paraffin-embedded human ovary carcinoma (A), normal cerebrum tissues (B), breast infiltrating carcinoma (C) and breast infiltrating carcinoma (D), showing cytoplasmic localization using STYK1/NOK mouse mAb with DAB staining. |
Type image 2 |
IHC |
Dilution image 2 |
1:200~~1000 |
Isotype |
IgG1 |
Calculated MW |
248426 |
Formulation |
Ascitic fluid containing 0.03% sodium azide. |
Description |
SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas. |
|
Clone: 7D7B11 |
Immunogen |
Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.