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EphB4 Antibody

EphB4 Antibody

Item no.	ABC-AO1056a
Manufacturer	Abcepta
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC, ELISA
Clone	5B8F7
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	EPHB4, HTK, MYK1, TYRO11, Ephrin type-B receptor 4, Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, 2.7.10.1
Available
Primary Accession	P54760
Antigen Type	Recombinant Protein
Application	WB, IHC, E
Bio References	1. J. Chrencik, A. Brooun, M. Recht. Structure. 2006 Feb; 14(2):321-30. 2. Qinghua WU, Zhenhe SUO, Bjon RISBERG. Pathol Oncol Res. 2004; 10(1):26-33.
Clonality	Monoclonal
Gene ID	2050
Gene Name	EPHB4
Subtitle	Purified Mouse Monoclonal Antibody
Reactivity	H
Legend image 1	Figure 1: Western blot analysis using EphB4 mouse mAb against truncated EphB4 recombinant protein.
Type image 1	WB
Dilution image 1	1/500 - 1/2000
Legend image 2	Figure 2: Immunohistochemical analysis of paraffin-embedded Human pancreas carcinoma (left) and breast carcinoma (right) tissue, showing membrane and cytoplasmic (pancreas carcinoma) localization, membrane (breast carcinoma) localization using EphB4 mouse mAb with DAB staining.
Type image 2	IHC
Dilution image 2	1/200 - 1/1000
Isotype	IgG2a
Calculated MW	108270
Formulation	Ascitic fluid containing 0.03% sodium azide.
Description	EPH receptor B4 (EphB4), with 987-amino acid protein (about 108kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptor tyrosine kinases and their ligands, the ephrins, regulate numerous biological processes in developing and adult tissues and have been implicated in cancer progression and in pathological forms of angiogenesis. EphB4 acts as a negative regulator of blood vessel branching and vascular network formation, switching the vascularization program from sprouting angiogenesis to circumferential vessel growth. EphB4 and its ligand ephrinB2 express in several kinds of tumor cells and correlate with tumorigenesis. EphB4 is thus a potential candidate as a predictor of disease outcome in several kinds of tumor and as target for novel therapy.
	Clone: 5B8F7
Immunogen	Purified recombinant fragment of EphB4 expressed in E. Coli.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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