RHOA

Item no.	ABC-AM8718b-ev-50ul
Manufacturer	Abcepta
Amount	50 ul
Category	Antibodies Cell Biology Cytoskeleton Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	Western Blot
Specific against	other
Host	Mouse
Isotype	IgG1 kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Transforming protein RhoA, Rho cDNA clone 12, h12, RHOA, ARH12, ARHA, RHO12
Available
Primary Accession	P61586
Antigen Type	Recombinant Protein
Bio Background	Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695).
Bio References	Yeramian P., et al.Nucleic Acids Res. 15:1869-1869(1987). Fagan K.P., et al.Exp. Eye Res. 59:235-237(1994). Puhl H.L. III, et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. Kalnine N., et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. Suzuki Y., et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gene ID	387
Gene Name	RHOA (HGNC:667)
Reactivity	H, M, Rat
Predicted	H, M, Rat
Calculated MW	21768
Antigen Source	HUMAN
Target/Specificity	This antibody is generated from a mouse immunized with a recombinant protein from human.

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Amount: 50 ul

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