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CASP3 Antibody

CASP3 Antibody

Item no.	ABC-AM2239b-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies Cell Biology Cell Status Apoptosis Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	Western Blot
Specific against	other
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, CASP3, CPP32
Available
Primary Accession	P42574
Antigen Type	Recombinant Protein
Bio Background	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Bio References	Choudhary C., et al. Science 325:834-840(2009). Fernandes-Alnemri T., et al. J. Biol. Chem. 269:30761-30764(1994). Tewari M., et al. Cell 81:801-809(1995). Pelletier M., et al. Biochem. Biophys. Res. Commun. 316:93-99(2004). Ota T., et al. Nat. Genet. 36:40-45(2004).
Gene ID	836
Gene Name	CASP3
Reactivity	H
Calculated MW	31608
Antigen Source	Human
Target/Specificity	Purified His-tagged CASP3 protein was used to produced this monoclonal antibody.
NCBI Accession	NP_004337.2; NP_116786.1

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Amount: 80 ul

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