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ALDH1A1 Antibody

ALDH1A1 Antibody

Item no.	ABC-AM1846b-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Adenocarcinoma Cytoskeleton Immunohistochemistry Western Blot Primary Antibodies Lung Cancer Colorectal Cancer
Type	Antibody Monoclonal
Applications	Western Blot, Immunohistochemistry
Clone	RB49670
Specific against	other
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Retinal dehydrogenase 1, RALDH 1, RalDH1, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic, ALDH1A1, ALDC, ALDH1, PUMB1
Available
Primary Accession	P00352
Other Accession	NP_000680.2
Antigen Type	Recombinant Protein
Bio Background	ALDH1A1 encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis.
Bio References	References for protein: 1.Gong, Y., et al. Oncogene 28(12):1549-1560(2009) 2.Burman, J.L., et al. J. Biol. Chem. 283(33):22774-22786(2008) 3.Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007) References for HepG2 cell line: 1. Knowles BB, et al. (1980). Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209: 497-499.[ PubMed: 6248960]. 2. Darlington GJ, et al. (1987). Growth and hepatospecific gene expression of human hepatoma cells in a defined medium. In Vitro Cell. Dev. Biol. 23: 349-354.[PubMed: 3034851]. 3. Ihrke, G; Neufeld, EB; Meads, T; Shanks, MR; Cassio, D; Laurent, M; Schroer, TA; Pagano, RE et al. (1993). "WIF-B cells: an in vitro model for studies of hepatocyte polarity". Journal of Cell Biology 123 (6): 1761-1775. [PubMed:7506266]. 4. Mersch-Sundermann, V.; Knasmüller, S.; Wu, X. J.; Darroudi, F.; Kassie, F. (2004). "Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents". Toxicology 198 (1-3): 329-340. [PubMed:15138059].
Gene ID	216
Gene Name	ALDH1A1 (HGNC:402)
Reactivity	H
Calculated MW	54862
Antigen Source	HUMAN
Target/Specificity	This ALDH1A1 monoclonal antibody is generated from mouse immunized with ALDH1A1 recombinant protein.
NCBI Accession	NP_000680.2

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Amount: 80 ul

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