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RTN4 / Nogo Antibody (Internal)

RTN4 / Nogo Antibody (Internal)

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Applications	IHC-P
Amount	50 ug
Host	Goat
Item no.	ABC-ALS13214
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	Q9NQC3
Antigen Type	Synthetic peptide
Application	IHC-P
Bio Background	Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Bio References	Yang J., et al.Cytogenet. Cell Genet. 88:101-102(2000). Prinjha R., et al.Nature 403:383-384(2000). Tagami S., et al.Oncogene 19:5736-5746(2000). Zhou Z.M., et al.Reproduction 123:227-234(2002). Oertle T., et al.J. Mol. Biol. 325:299-323(2003).
Clonality	Polyclonal
Gene ID	57142
Gene Name	RTN4 (HGNC:14085)
Subtitle	Goat Polyclonal Antibody
Reactivity	H, Pr
Legend image 1	Anti-RTN4 / Nogo antibody IHC of human brain, cortex.
Type image 1	IHC
Legend image 2	Anti-RTN4 / Nogo antibody IHC of human testis.
Type image 2	IHC
Calculated MW	129931
Target/Specificity	Human RTN4 / Nogo. This antibody is expected to recognize reported isoform A (NP_065393.1) and isoform E (NP_997404.1).
Purification	Immunoaffinity purified
Concentration (mg/ml)	0.5 mg/ml
Reconstitution & Storage	Store at -20°C. Minimize freezing and thawing.
Dilution	IHC-P (2.5 µg/ml)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 50 ug

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Delivery expected until 8/2/2024