Manufacturer |
Abcepta
|
Category |
|
Type |
Antibody Primary |
Specific against |
other |
Applications |
WB, ELISA, IHC-P |
Amount |
50 ug |
Host |
Goat |
Item no. |
ABC-ALS13073 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Primary Accession |
Q9Y261 |
Antigen Type |
Synthetic peptide |
Application |
WB, IHC-P, E |
Bio Background |
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
Bio References |
Yamada S., et al.Diabetologia 43:121-124(2000).Hinokio Y., et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.Navas M.A., et al.Hum. Hered. 50:370-381(2000).Deloukas P., et al.Nature 414:865-871(2001).Wolfrum C., et al.Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003). |
Clonality |
Polyclonal |
Gene ID |
3170 |
Gene Name |
FOXA2 |
Subtitle |
Goat Polyclonal Antibody |
Reactivity |
H, M, Rat, Rb, Ha, Pr, Pig, C, Hs, X, B, Dog |
Legend image 1 |
Anti-FOXA2 antibody IHC of human prostate. |
Type image 1 |
IHC |
Calculated MW |
48306 |
Target/Specificity |
Human FOXA2. This antibody is expected to recognise both reported isoforms. |
Purification |
Immunoaffinity purified |
Concentration (mg/ml) |
0.5 mg/ml |
Reconstitution & Storage |
Store at -20°C. Minimize freezing and thawing. |
Dilution |
ELISA (1:2000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.