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Goat Anti-TIRAP / Mal (Isoform b) Antibody

Goat Anti-TIRAP / Mal (Isoform b) Antibody

Item no.	ABC-AF2092a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, ELISA
Specific against	other
Host	Goat
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TIRAP, MAL, MyD88 adapter-like protein, Toll/interleukin-1 receptor domain-containing adapter protein, TIR domain-containing adapter protein, Adaptor protein Wyatt, MyD88-2
Available
Primary Accession	P58753
Antigen Type	Synthetic Peptide
Application	WB, E
Bio Background	The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Bio References	Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India. Selvaraj P, et al. Tuberculosis (Edinb), 2010 Sep. PMID 20797905. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308. Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis. Plantinga TS, et al. J Acquir Immune Defic Syndr, 2010 Sep 1. PMID 20577092. Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Kumpf O, et al. Crit Care, 2010. PMID 20525286.
Clonality	Polyclonal
Gene ID	114609
Gene Name	TIRAP
Subtitle	Peptide-affinity purified goat antibody
Reactivity	H
Legend image 1	AF2092a (1 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 1	WB
Other Accession	NP_683708; 114609;
Concentration (mg/ml)	100ug/200ul

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 11/8/2024

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