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Goat Anti-SPHK1 Antibody

Goat Anti-SPHK1 Antibody

Item no.	ABC-AF2031a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IP, ELISA
Specific against	other
Host	Goat
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	SPHK1, SPK, SPHK, Sphingosine kinase 1, SK 1, SPK 1, 2.7.1.91
Available
Primary Accession	Q9NYA1
Antigen Type	Synthetic Peptide
Application	WB, E, IP
Bio Background	Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.
Bio References	SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Puneet P, et al. Science, 2010 Jun 4. PMID 20522778. Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity. Seo YJ, et al. J Virol, 2010 Aug. PMID 20519401. Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells. Illuzzi G, et al. J Biol Chem, 2010 Jun 11. PMID 20404323. New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496. CXCL4-induced monocyte survival, cytokine expression, and oxygen radical formation is regulated by sphingosine kinase 1. Kasper B, et al. Eur J Immunol, 2010 Apr. PMID 20104488.
Clonality	Polyclonal
Gene ID	8877
Gene Name	SPHK1 (HGNC:11240)
Subtitle	Peptide-affinity purified goat antibody
Reactivity	H
Legend image 1	AF2031a (2 µg/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 1	WB
Other Accession	NP_892010; 8877; 20698 (mouse); 170897 (rat);
Predicted	M, Rat, Cow, Dog
Concentration (mg/ml)	100ug/200ul

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/4/2024

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