Bio Background |
Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum. |
Bio References |
SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Puneet P, et al. Science, 2010 Jun 4. PMID 20522778.Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity. Seo YJ, et al. J Virol, 2010 Aug. PMID 20519401.Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells. Illuzzi G, et al. J Biol Chem, 2010 Jun 11. PMID 20404323.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.CXCL4-induced monocyte survival, cytokine expression, and oxygen radical formation is regulated by sphingosine kinase 1. Kasper B, et al. Eur J Immunol, 2010 Apr. PMID 20104488. |