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Goat Anti-SIRT1 Antibody

Goat Anti-SIRT1 Antibody

Item no.	ABC-AF1993a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, ELISA
Specific against	other
Host	Goat
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	SIRT1, SIR2L1, NAD-dependent protein deacetylase sirtuin-1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, 75SirT1, SirtT1 75 kDa fragment, 3.5.1.-
Available
Primary Accession	Q96EB6
Antigen Type	Synthetic Peptide
Application	WB, E
Bio Background	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Bio References	SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Fan W, et al. Mol Cell, 2010 Jul 30. PMID 20670893. SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. Satoh A, et al. J Neurosci, 2010 Jul 28. PMID 20668205. SIRT1 variants are associated with aging in a healthy Han Chinese population. Zhang WG, et al. Clin Chim Acta, 2010 Nov 11. PMID 20633545. Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Calvanese V, et al. Proc Natl Acad Sci U S A, 2010 Aug 3. PMID 20631301. MicroRNA-34a regulation of endothelial senescence. Ito T, et al. Biochem Biophys Res Commun, 2010 Aug 6. PMID 20627091.
Clonality	Polyclonal
Gene ID	23411
Gene Name	SIRT1 (HGNC:14929)
Subtitle	Peptide-affinity purified goat antibody
Reactivity	M
Legend image 1	AF1993a (1 µg/ml) staining of Mouse fetal Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 1	WB
Other Accession	NP_036370; 23411; 93759 (mouse); 309757 (rat);
Predicted	H, Rat, Dog
Concentration (mg/ml)	100ug/200ul

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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