Bio Background |
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]). |
Bio References |
Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells. Ueki T, et al. Cancer Res, 2009 Nov 15. PMID 19887602.FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. Longerich S, et al. J Biol Chem, 2009 Aug 28. PMID 19589784.Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. Alpi AF, et al. Mol Cell, 2008 Dec 26. PMID 19111657.Elevated expression of UBE2T in lung cancer tumors and cell lines. Hao J, et al. Tumour Biol, 2008. PMID 18667844.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348. |