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DNMT3B polyclonal antibody

DNMT3B polyclonal antibody

Item no.	ABC-ADN10134
Manufacturer	Abcepta
Amount	50 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IF, ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Dnmt3b, DNMT3B, DNA (cytosine-5)-methyltransferase 3B, DNA methyltransferase HsaIIIB, M.HsaIIIB, DNA MTase HsaIIIB, 2.1.1.37
Available
Primary Accession	Q9UBC3
Application	WB, IF, E
Bio Background	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
Bio References	Xie S., et al.Gene 236:87-95(1999). Xu G.-L., et al.Nature 402:187-191(1999). Ni J., et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. Ota T., et al.Nat. Genet. 36:40-45(2004). Deloukas P., et al.Nature 414:865-871(2001).
Clonality	Polyclonal
Gene ID	1789
Gene Name	DNMT3B
Subtitle	Purified Rabbit Polyclonal Antibody
Reactivity	H
Legend image 1	Determination of the antibody titer
Type image 1	E
Legend image 2	Western blot analysis using the antibody directed against DNMT3B
Type image 2	WB
Legend image 3	Immunofluorescence using the antibody directed against DNMT3B
Type image 3	IF

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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