Anti-VDAC/Porin Antibody

P21796

Polyclonal

H, M, Rat

WB

Anti-VDAC/Porin antibody, ABO11086, IHC(P)IHC(P): Rat Cardiac Muscle Tissue

0.5-1 µg/ml

IHC

ICC

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. .

Heart, liver and skeletal muscle.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

At -20?C for one year. After r?Constitution, at 4?C for one month. It?Can also be aliquotted and stored frozen at -20?C for a longer time.Avoid repeated freezing and thawing.

Belongs to the eukaryotic mitochondrial porin family.