Item no. |
ABC-ABO11038 |
Manufacturer |
Abcepta
|
Amount |
100 ug |
Category |
|
Type |
Antibody Primary |
Format |
Lyophilized |
Applications |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
PAK-6, PAK6, PAK5, Serine/threonine-protein kinase PAK 6, PAK-5, p21-activated kinase 6, 2.7.11.1 |
Available |
|
Primary Accession |
Q9NQU5 |
Application |
WB, IHC-P |
Clonality |
Polyclonal |
Gene ID |
106821730; 56924 |
Reactivity |
H, M, Rat |
Legend image 1 |
Anti-PAK6 antibody, ABO11038, Western blottingAll lanes: Anti PAK6 (ABO11038) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: 293T Whole Cell Lysate at 40ugLane 3: RAJI Whole Cell Lysate at 40ugLane 4: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 75KDObserved bind size: 75KD |
Type image 1 |
WB |
Dilution image 1 |
0.1-0.5 µg/ml |
Legend image 2 |
Anti-PAK6 antibody, ABO11038, IHC(P)IHC(P): Rat Brain Tissue |
Type image 2 |
IHC |
Dilution image 2 |
0.5-1 µg/ml |
Calculated MW |
74869 |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Description |
Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase PAK 6(PAK6) detection. Tested with WB, IHC-P in Human; Rat; Mouse. |
Protein Function |
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. . |
Subcellular Localization |
Cytoplasm. Nucleus. Cotranslocates into nucleus with AR in response to androgen induction. |
Tissue Specificity |
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. . |
Protein Name |
Serine/threonine-protein kinase PAK 6 |
Contents |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Immunogen |
A synthetic peptide corresponding to a sequence at the N-terminus of human PAK6(16-32aa QNFQHRVHTSFDPKEGK), identical to the related rat and mouse sequences. |
Purification |
Immunogen affinity purified. |
Cross Reactivity |
No cross reactivity with other proteins |
Storage |
At -20?C for one year. After r?Constitution, at 4?C for one month. It?Can also be aliquotted and stored frozen at -20?C for a longer time.Avoid repeated freezing and thawing. |
Concentration (mg/ml) |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Sequence Similarities |
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.