LATS1/LATS2 Rabbit pAb

Serine/threonine-protein kinase LATS1 and LATS2 are negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. LATS1 acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. LATS1 negatively regulates G2/M transition by down-regulating CDK1 kinase activity. LATS1 is involved in the control of p53 expression and actin polymerization through negative modulation of LIMK1. LATS2 also acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. LATS2 negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.

Polyclonal Antibodies

Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.

LATS1/LATS2