Anti-MCM2 Rabbit mAb

Uncategorized

Store at -20°C. Avoid freeze/thaw cycles.

Anti-MCM2 Rabbit mAb

PBS, Glycerol, BSA

Recombinant Monoclonal

MCM2 is a nuclear protein that plays an important role in the key steps of DNA replication and cell division in the cell cycle. The content of MCM2 is very low in cells in the quiescent phase, while in proliferating and transformed cells, the content of MCM2 begins to increase in the G0 phase, reaches a peak at the end of G0 and early s, and binds to chromatin, and is free from the s phase to the M phase. MCM2, G2 phase and M phase decreased. Due to this cyclical change consistent with the cell proliferation process, MCM2 has now been regarded as a marker for cells in the s phase, and it is also a specific proliferation-related factor, reflecting the cell proliferation activity. MCM2 protein can distinguish the corresponding normal tissues, dysplastic tissues and tumor tissues. In reproductive system tumors, gastric cancer, and other cancer tissues, the expression index of MCM2 protein is positively correlated with histological grade and Nottingham prognostic index, that is: the higher the MCM2 protein expression index, the higher the malignancy of the tumor, and the patient’s The worse the prognosis, the greater the risk of death, and it has more predictive significance than Ki67. In short, MCM2 protein is used in clinic as a cell proliferation marker, and it has certain significance for the diagnosis and prognosis of precancerous lesions and malignant tumors.