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Anti-CD31 Rabbit mAb

Anti-CD31 Rabbit mAb

Item no.	PTM-5643
Manufacturer	PTM Biolabs
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Lyophilized powder
Applications	WB, FC, IP, ICC, IHC-P
Clone	JRMR-10129-3
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	EndoCAM, GPIIA', PECA1, PECAM1, PECAM-1
Shipping condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Uncategorized
Manufacturer - Targets	CD31
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight	125
Manufacturer - Research Area	Cancer
Product description	Anti-CD31 Rabbit mAb
Purification Method	Protein A purified
Manufacturer - Specificity	Anti-CD31 Rabbit mAb recognizes endogeneous level of CD31 protein.
Constituents	PBS, Glycerol, BSA
PTM	Unmodified
Immunogen	Recombinant human CD31 fragment
Clonality	Recombinant Monoclonal
Stability	Stable for 12 months from date of receipt/reconstitution.
Background	Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells.
Cellular Localization	Membrane

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 1/17/2025