Comparison

Anti-β-Hydroxybutyryl-Histone H2B (Lys15) Rabbit mAb

Item no. PTM-1233RM
Manufacturer PTM Biolabs
Amount 100 ul
Category
Type Antibody Monoclonal
Format Lyophilized powder
Applications WB
Clone PA-109-16
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias H2BK15bhb
Shipping condition Room temperature
Available
Manufacturer - Type
Primary Antibodies
Manufacturer - Category
Histone & Histone Modification Antibodies
Manufacturer - Targets
Histone H2B
Storage Conditions
Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight
14
Manufacturer - Research Area
Epigenetics
Product description
Anti-β-Hydroxybutyryl-Histone H2B (Lys15) Rabbit mAb
Purification Method
Protein A purified
Manufacturer - Specificity
Anti-β-Hydroxybutyryl-Histone H2B (Lys15) Rabbit mAb detects histone H2B only when it is β-hydroxybutyrylated at Lys15. This antibody has been shown to selectively recognize β-Hydroxybutyrylated H2B peptide at Lys15, but not the acetylated, crotonylated, butyrylated, or unmodified H2B peptide at Lys15.
Constituents
PBS, Glycerol, BSA
PTM
β-Hydroxybutyryl
Modification Site
Lys15
Immunogen
β-Hydroxybutylated human histone H2B (Lys15) peptide
Clonality
Recombinant Monoclonal
Stability
Stable for 12 months from date of receipt/reconstitution.
Background
Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, etc. β-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone β-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.
Cellular Localization
Nucleus

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
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