Mouse Monoclonal Antibody to GRIA2

Catalog Number: sAP-1565
Product Name: Mouse Monoclonal Antibody to GRIA2
Target Molecle: GRIA2
Aliases: GLUR2; GLURB; GluA2; HBGR2; GluR-K2
Species: Human;
MW: 99kDa
Enterez GeneID: 2891
General Information: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG
CGG; Q
R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
Immunogen: Purified recombinant fragment of human GRIA2 (AA: 35-175) expressed in E. Coli.
Clone: MM7A7A3
Isotype: Mouse IgG2b
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; ICC: N to A; FCM: 1 to 200 - 1 to 400; IHC: 1 to 200 - 1 to 1000
References: 1.Nat Commun. 2015 Jul 6; 6:7538. 2.Oncotarget. 2015 Jul 20; 6(20):18105-15.