Mouse Monoclonal Antibody to CRTC3

Catalog Number: sAP-0521
Product Name: Mouse Monoclonal Antibody to CRTC3
Target Molecle: CRTC3
Aliases: TORC3; FLJ21868; CRTC3
Species: Human; Monkey
MW: 68kDa
Enterez GeneID: 64784
General Information: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
Immunogen: Purified recombinant fragment of human CRTC3 expressed in E. Coli.
Clone: MM5G9;
Isotype: Mouse IgG1
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: 1 to 200 - 1 to 1000; ICC: 1 to 200 - 1 to 1000
References: 1. J Biol Chem. 2009 Jan 2; 284(1):685-95. ; 2. J Immunol. 2008 Sep 1; 181(5):3252-8.