Mouse Monoclonal Antibody to CD86

Catalog Number: sAP-0459
Product Name: Mouse Monoclonal Antibody to CD86
Target Molecle: CD86
Aliases: B70; B7-2; LAB72; CD28LG2; MGC34413; CD86
Species: Human
MW: 52kDa
Enterez GeneID: 942
General Information: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.Tissue specificity: Expressed by activated B-lymphocytes and monocytes.
Immunogen: Purified recombinant fragment of human CD86 expressed in E. Coli.
Clone: MM1B3;
Isotype: Mouse IgG1
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000
References: 1. Mol Cancer. 2010 Jan 5; 9:1. ; 2. J Infect Dis. 2010 May 1; 201(9):1371-80.