Mouse Monoclonal Antibody to KLHL13

Catalog Number: sAP-0420
Product Name: Mouse Monoclonal Antibody to KLHL13
Target Molecle: KLHL13
Aliases: BKLHD2; FLJ10262; MGC74791; KLHL13
Species: Human
MW: 74kDa
Enterez GeneID: 90293
General Information: KLHL13 (kelch-like 13), also known as BKLHD2 (BTB and kelch domain-containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate- specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.
Immunogen: Purified recombinant fragment of human KLHL13 expressed in E. Coli. ;
Clone: MM8D1;
Isotype: Mouse IgG1
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide. ;
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: 1 to 200 - 1 to 1000; ICC: 1 to 200 - 1 to 1000; FCM: 1 to 200 - 1 to 400
References: 1.Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2581-90. ; 2.J Biol Chem. 2009 Oct 2; 284(40):27524-32. ; 3.J Biol Chem. 2010 Jan 22; 285(4):2527-36.