Mouse Monoclonal Antibody to ITGA5

Catalog Number: sAP-0336
Product Name: Mouse Monoclonal Antibody to ITGA5
Target Molecle: ITGA5
Aliases: FNRA; CD49e; VLA5A; ITGA5
Species: Human
MW: 114kDa
Enterez GeneID: 3678
General Information: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.
Immunogen: Purified recombinant fragment of human ITGA5 expressed in E. Coli.
Clone: MM10F6;
Isotype: Mouse IgG2a
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: 1 to 200 - 1 to 1000; FCM: 1 to 200 - 1 to 400
References: 1. J Invest Dermatol. 1999. 112(3):362-9 ; 2. Exp Cell Res. 2006. 254(1):80-90 ; 3. Mol Cell Biol. 2000. 24(8):3168-79