Description |
Catalog Number: sAP-0258 Product Name: Mouse Monoclonal Antibody to R-spondin1 Target Molecle: R-spondin1 Aliases: RSPO1; CRISTIN3; FLJ40906 Species: Human MW: 28.9kDa Enterez GeneID: 284654 General Information: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Immunogen: Purified recombinant fragment of R-spondin1 expressed in E. Coli. ; Clone: MM7A6; Isotype: Mouse IgG1 Size and Concentration: 100ug/1mg/ml Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide. Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage. Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000 References: 1. Leukemia. 2008 Dec; 22(12):2201-7. ; 2. J Immunol. 2008 Feb 1; 180(3):1490-8. ; |