Manufacturer |
American Research Products
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Amount |
100 ug |
Item no. |
ARP-11-IL-16HT-100 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Description |
Interleukin-16 (IL16) is an immunomodulatory cytokine, which induces lymphocyte migration, expression of proinflammatory IL-1beta, IL6 and tumour necrosis factor-alpha (TNFalpha), and modulates apoptosis. This protein is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. Also, several central nervous system diseases and may play a role in promoting inflammatory responses. Recombinant human IL16, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Form |
Liquid in 20mM Tris pH 8.0, 1mM DTT, 10%glycerol |
Storage |
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Synonyms |
LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289, IL 16, Lymphocyte chemoattractant factor, HGNC:5980, Interleukin 16 precursor, PrIL16, |
Concentration |
1 mg/ml (determined by Bradford assay) |
NCBI |
NP_004504 |
References |
- Bernstein HB., et al. (2006) J Immunol. 177(6):3669-76.
- McFadden C J., et al. (2007) J Immunol. 179(10):6439-45.
|
Antigen Recognized in Species |
Human |
Purity |
>, 95% by SDS - PAGE |
Molecular Weight |
15.5kDa (150aa), confirmed by MALDI-TOF. |
Amino Acid Sequence |
MGSSHHHHHH SSGLVPRGSH MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS |
Gene Category |
Hormones &, Cytokines |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.