Item no. |
ARP-01-2145-100 |
Manufacturer |
American Research Products
|
Amount |
100 ug |
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Description |
AHSP(Alpha-hemoglobin stabilizing protein), also known as ERAF(Erythroid associated factor), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of alpha-hemoglobin during normal erythroid cell development. It specifically protects free alpha-hemoglobin from precipitation in live cells and in solution. This protein is downregulated in transmissible spongiform encephalopathies (TSEs). It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Recombinant AHSP protein was expressed in E.coli and purified by using conventional chromatography techniques. |
Form |
Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 10% glycerol |
Storage |
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Synonyms |
ERAF, EDRF, Alpha-hemoglobin stabilizing protein Alpha hemoglobin stabilizing protein, Erythroid associated factor, Erythroid differentiation associated factor, Erythroid differentiation related factor, |
Concentration |
1 mg/ml (determined by Bradford assay) |
NCBI |
NP_057717 |
References |
- Dos Santos CO., et al. (2008) J Biol Chem. 283(40):26956-64.
- Sekijima Y., et al. (2005) Cell. 121(1):73-85.
|
Antigen Recognized in Species |
Human |
Purity |
>, 95% by SDS - PAGE |
Molecular Weight |
11.8 kDa (102aa), confirmed by MALDI-TOF. |
Amino Acid Sequence |
MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS |
Gene Category |
Heat Shock Proteins |
Endotoxin Level |
<, 1.0 EU per 1 microgram of protein (determined by LAL method) |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.