Anti-Transferrin Receptor 2 (TFR2)

Transferrin receptor protein 2 is a protein that is encoded by the TFR2 gene. This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized.TFR2-alpha was expressed in the liver, spleen, lung, muscle, prostate, and peripheral blood mononuclear cells, whereas expression of TFR-beta was found in all tissues tested.

Western blotting: 1:100-400, Immunocytochemistry in formalin fixed cells: 1:100-500, Immunohistochemistry in formalin fixed frozen section: 1:100-500, Immunohistochemistry in paraffin section: 1:50-417

HFE3, TFRC2

Chicken