Item no. |
ARP-03-11160 |
Manufacturer |
American Research Products
|
Amount |
100 ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
IF, ELISA |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Available |
|
Background |
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. |
Immunogen |
Serotonin/Ovalbumin |
Form |
Serum containing 0.1% sodium azide |
Specificity |
The polyclonal antibody to serotonin can be used to differentiate tumors of serotoninergic origin. The antigen localization is cytoplasmic. |
Working Dilution |
1:25 for immunohistochemistry (optimal dilution should be tested by serial dilution) |
Storage |
2-8C for immediate use, or at -20C (aliquot) |
Synonyms |
HTT, 5HTT, OCD1, SERT, 5-HTT, SERT1, hSERT, 5-HTTLPR |
References |
Arends JW et al. (1986) J Pathology 149: 97-102 |
Antigen Recognized in Species |
Most species, incl. Human, Mouse, Rat |
Positive Control |
Duodenum/Formalin-fixed paraffin sections of human intestine |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.