Mouse TSC2 (pS1421) Antibody

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).

PBS containing 0.09% sodium azide.

Calculated MW: 202 kDa

Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

TSC2_MOUSE