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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

Item no.	abx002034-50
Manufacturer	Abbexa
Amount	50 ul
Category	Neuroscience Aging & Neurological Disorders Antibodies Cell Biology Cell Status Immunohistochemistry Immunoprecipitation Western Blot Autophagy Primary Antibodies
Type	Antibody Primary
Applications	WB, IP, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	SYVN1
Available
Antigen	SYVN1
Description	SYVN1 Antibody is a Rabbit Polyclonal antibody against SYVN1. HRD1is also named as SYVN1(Synovial apoptosis inhibitor 1), KIAA1810. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Two distinct binding sites mediate Hrd1 dimerization or oligomerization, one located within the transmembrane region and another within the cytosolic domain. (PMID:19864457).Western blot analysis detected abundant HRD1 expression in liver and kidney. Mouse liver and spleen expressed Hrd1 as an 85-kD protein(PMID:12646171).This antibody is specific to HRD1.
Conjugation	Unconjugated
Purification	Affinity purified.
Storage	Aliquot and store at -20C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q86TM6
UniProt Entry Name	SYVN1_HUMAN
Gene Symbol	SYVN1
Gene ID	84447
Molecular Weight	Calculated MW: 61 kDa, 67 kDa Observed MW: 72 kDa
Buffer	PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Dry Ice	No
Note	This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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