Glutamate Decarboxylase 2 (GAD2) Antibody

Polyclonal Antibody to Glutamate Decarboxylase 2 (GAD2). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

GAD2

138275

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

DCE2_HUMAN