Recombinant Human TWEAK (CD255) (Carrier-free)

The TNF-like weak inducer of apoptosis (TWEAK) cytokine belongs to the TNF superfamily of proteins that can exist in membrane bound or soluble formats. As its name suggests, it is not as effective in inducing apoptosis as TNF, and is limited to fewer cell targets. TWEAK can induce chemokine production, promote angiogenesis, and can induce proliferation and migration of endothelial cells. TWEAKR, alternatively known as FN14 or CD266, has been described as a receptor for TWEAK. DR3 (Death Receptor 3) has also been suggested as a receptor for TWEAK. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes.

MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWAHLK AAPFLTYFGL FQVH

Assay #1: The ED₅₀ as determined by the dose-dependent stimulation of IL-8 production by Human PBMC is less than 10 ng/ml.
Assay #2: TWEAK weakly induces the death of HT29 cells when cul

Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein.

Angiogenesis/Cardiovascular; Apoptosis; Inflammation; Neurobiology; Proliferation; TNF Superfamily

See Certificate of Analysis (COA) for lot specific reconstitution information.