ArtNr |
21-7069-U010 |
Hersteller |
Tonbo Biosciences
|
Menge |
10 ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
Human |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Description |
IGF-II (insulin-like growth factor II) is a member of a family of proteins involved in mediating growth and development. IGF-II expression is regulated by lactogen, is expressed in many cell and tissue types, and may have autocrine, paracrine and endocrine functions. IGF-II binds with higher affinity to IGF-R II than IGF-R I. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. As with IGF-I, association with IGF binding proteins acts to extend the half-life of IGF-II and regulates receptor interaction. |
Alternative Names |
Insulin-like Growth Factor-I, Somatamedin C, IGF-IA |
Amino Acid Sequence |
AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE |
Authenticity |
Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
Bioactivity |
The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. |
Endotoxin Level |
Endotoxin level is < 0.1 ng/µ g of protein ( < 1EU/µ g). |
Molecular Mass |
Recombinant human IGF-II is a globular protein containing 67 amino acids and 3 intra-molecular disulfide bonds, and has a predicted molecular mass of approximately 7.47 kD. |
Protein Content |
Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
Research Areas |
Angiogenesis/Cardiovascular; Bone, Skeletal, Cartilage; Diabetes / Weight Regulation; Inflammation; Proliferation; Wound Healing |
Purity |
98% |
Reconstitution |
See Certificate of Analysis (COA) for lot specific reconstitution information. |
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