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Purified Anti-Mouse Ly-6G (Gr-1) (RB6-8C5) Europäischer Partner

ArtNr 70-5931-U100
Hersteller Tonbo Biosciences
Menge 100 ug
Kategorie
Typ Antibody Monoclonal
Format Purified
Applikationen FC, IP, FA, IHCF, IHCP
Clon RB6-8C5
Specific against Mouse
Host Rat
Isotype IgG2b kappa
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Gr1, Ly6G
Similar products Gr-1
Lieferbar
Description

The RB6-8C5 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils. In the mouse, the RB6-8C5 antibody is typically used in combination with the macrophage labeling antibody M1/70 (Anti-CD11b) for phenotypic analysis of monocytes, macrophages and granulocytes.


Note: The RB6-8C5 antibody has been reported to cross-react with Ly-6C on cells expressing this antigen (Fleming et al. 1993. J. Immunol. 151:2399-2408 and Sasmono et al. 2007. J. Leukoc. Biol. 82: 111-123) and has been cited in the literature for identification of Ly-6G/Ly-6C. Other reports suggest that this antibody is specific for Ly-6G, without cross-reactivity for Ly-6C (Nagendra S. and Schlueter AJ. 2003. Cytometry A, 58(2): 195-200.


Alternative Names
Gr1, Ly6G
Gene ID
17067
Citations

Berent-Maoz B, Montecino-Rodriguez E, Signer RAJ, and Dorshkind K. 2012. Blood. 199:5715-5721. (Flow cytometry)


von Bruhl M-L, Stark K, Steinhart A, et al. 2012. J. Exp. Med. 209: 819-835. (Intravital fluorescent microscopy - video)


Le HT, Tran VG, Kim W, Kim H, Cho HR, and Kwon B. 2012. J. Immunol. 189:287-295. (in vivo neutrophil depletion)


Doring Y, Soehnlein O, Drechsler M, Shagdarsuren E, Chaudhari SM, Meiler S, Hartwig H, Hristov M, Koenen RR, Hieronymus T, Zenke M, Weber C, and Zernecke A. 2012. Arterioscler. Thromb. Vasc. Biol. 32: 1613-1623. (in vivo depletion)


Hickman HD, Li L, Reynoso GV, Rubin EJ, Skon CN, Mays JW, Gibbs J, Schwartz O, Bennink JR, and Yewdell JW. 2011. J. Exp. Med. 208: 2511-2524. (Immunohistochemistry - OCT embedded frozen tissue)


Wang T, Tian L, Haino M, Gao J-L, Lake R, Ward Y, Wang H, Siebenlist U, Murphy PM, and Kelly K. 2007. Infect. Immun. 75(3):1144-1153. (Immunohistochemistry - zinc fixed tissue)


Nutt SL, Metcalf D, D´ Amico A, Polli M, and Wu L. 2005. J. Exp. Med. 201:221-231. (Immunomagnetic bead depletion)


Whiteland JL, Nicholls SM, Shimeld C, Easty DL, Williams NA, and Hill TJ. 1995. J. Histochem. Cytochem. 43:313-320. (Immunohistochemistry - frozen tissue, paraffin embedded tissue)


Fleming TJ, Fleming ML, and Malek TR. 1993. J. Immunol. 151:2399-2408. (in vitro blocking, immunoprecipitation)


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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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