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Anti-EGLN1 antibody

Anti-EGLN1 antibody

ArtNr	STJ116768-100
Hersteller	St John's Laboratory
Menge	100ul
Kategorie	Antibodies Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB
Specific against	Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Anti-Egl Nine Homolog 1 antibody</br>Anti-Hypoxia-Inducible Factor Prolyl Hydroxylase 2 antibody</br>Anti-Hif-Ph2 antibody</br>Anti-Hif-Prolyl Hydroxylase 2 antibody</br>Anti-Hph-2 antibody</br>Anti-Prolyl Hydroxylase Domain-Containing Protein 2 antibody<
Similar products	Anti-Egl Nine Homolog 1 antibody Anti-Hypoxia-Inducible Factor Prolyl Hydroxylase 2 antibody Anti-Hif-Ph2 antibody Anti-Hif-Prolyl Hydroxylase 2 antibody Anti-Hph-2 antibody Anti-Prolyl Hydroxylase Domain-Containing Protein 2 antibody<
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Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification	Affinity purification
Uniprot ID	Q9GZT9
Storage	Store at-20° C and avoid freeze-thaw cycles.
Description	The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
Gene ID	54583
Gene symbol	EGLN1
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-426 of human EGLN1 (NP_071334. 1).
Short Description	Rabbit polyclonal against EGLN1
Tissue specificity	widely expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of adult and fetal substantia nigra) and kidney, and lower levels in lung and liver. widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle..expressed in adult and fetal heart, brain, liver, lung, skeletal muscle and kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung and liver and fetal brain, heart spleen and skeletal muscle.
Cellular localization	Cytoplasm Nucleus Mainly Cytoplasmic Shuttles Between The Nucleus And Cytoplasm Nuclear Export Requires Functional Xpo1
Molecular weight	Calculated: 36kDa/43kDa/46kDa. Observed: 46kDa
Dilution range	WB 1:500-1:2000
Alternative names	Anti-Egl Nine Homolog 1 antibody Anti-Hypoxia-Inducible Factor Prolyl Hydroxylase 2 antibody Anti-Hif-Ph2 antibody Anti-Hif-Prolyl Hydroxylase 2 antibody Anti-Hph-2 antibody Anti-Prolyl Hydroxylase Domain-Containing Protein 2 antibody Anti-Phd2 antibody Anti-Sm-20 antibody Anti-EGLN1 C1orf12 PNAS-118 PNAS-137 antibody
Protein name	Egl Nine Homolog 1 Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Hif-Ph2 Hif-Prolyl Hydroxylase 2 Hph-2 Prolyl Hydroxylase Domain-Containing Protein 2 Phd2 Sm-20
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	EGLN1_HUMAN

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Menge: 100ul

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Lieferung vsl. bis 27.09.2024

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