ArtNr |
STJ116044-50 |
Hersteller |
St John's Laboratory
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Nad-Dependent Protein Deacetylase Sirtuin-2 antibody</br>Anti-Regulatory Protein Sir2 Homolog 2 antibody</br>Anti-Sir2-Like Protein 2 antibody</br>Anti-SIRT2 SIR2L SIR2L2 antibody |
Similar products |
Anti-Nad-Dependent Protein Deacetylase Sirtuin-2 antibodyAnti-Regulatory Protein Sir2 Homolog 2 antibodyAnti-Sir2-Like Protein 2 antibodyAnti-SIRT2 SIR2L SIR2L2 antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q8IXJ6 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. |
Gene ID |
|
Gene symbol |
|
Immunogen |
A synthetic peptide of human SIRT2 |
Short Description |
Rabbit polyclonal against SIRT2 |
Tissue specificity |
Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. |
Cellular localization |
NucleusCytoplasmPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleSpindleMidbodyChromosomePerikaryonCell ProjectionGrowth ConeMyelin MembraneDeacetylates Foxo3 In The CytoplasmColocalizes With Plp1 In Internodal RegionsAt Paranodal Axoglial Junction And Schmidt-Lanterman Incisures Of Myelin SheatColocalizes With Cdk5r1 In The PerikaryonNeurites And Growth Cone Of Hippocampal NeuronsColocalizes With Alpha-Tubulin In Neuronal Growth ConeLocalizes In The Cytoplasm And Nucleus Of Germinal Vesicle (Gv) Stage OocytesColocalizes With Alpha-Tubulin On The Meiotic Spindle As The Oocytes Enter Into MetaphaseAnd Also During Meiotic Anaphase And TelophaseEspecially With The MidbodyColocalizes With Pard3 In Internodal Region Of AxonsColocalizes With Acetylated Alpha-Tubulin In Cell Projection Processes During Primary Oligodendrocyte Precursor (Olp) DifferentiationLocalizes In The Cytoplasm During Most Of The Cell Cycle Except In The G2/M Transition And During MitosisWhere It Is Localized In Association With Chromatin And Induces Deacetylation Of Histone At 'Lys-16' (H4k16ac)Colocalizes With Kmt5a At Mitotic FociColocalizes With Cdk1 At Centrosome During Prophase And Splindle Fibers During MetaphaseColocalizes With Aurora Kinase Aurka At Centrosome During Early Prophase And In The Centrioles And Growing Mitotic Spindle Throughout MetaphaseColocalizes With Aurora Kinase Aurkb During Cytokinesis With The MidbodyColocalizes With MicrotubulesDetected In Perinuclear Foci That May Be Aggresomes Containing MisfoldedUbiquitinated ProteinsShuttles Between The Cytoplasm And The Nucleus Through The Crm1 Export PathwayColocalizes With Ep300 In The NucleusTranslocates To The Nucleus And Chromatin Upon Bacterium Listeria Monocytogenes Infection In Interphase CellsIsoform 1: CytoplasmPredominantly Localized In The CytoplasmicIsoform 2: CytoplasmIsoform 5: CytoplasmPredominantly Localized In The Nucleus |
Molecular weight |
Calculated: 30kDa/35kDa/39kDa/41kDa/43kDa. Observed: 39kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Nad-Dependent Protein Deacetylase Sirtuin-2 antibodyAnti-Regulatory Protein Sir2 Homolog 2 antibodyAnti-Sir2-Like Protein 2 antibodyAnti-SIRT2 SIR2L SIR2L2 antibody |
Protein name |
Nad-Dependent Protein Deacetylase Sirtuin-2Regulatory Protein Sir2 Homolog 2Sir2-Like Protein 2 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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