Anti-PP1C antibody

Monoclonal

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

P36873

1 mg/ml

5501

Purified recombinant human PP1C protein fragments expressed in E.coli.

Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Colocalizes with SPZ1 in the nucleus. Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase.

WB 1:500

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
PP-1G
Protein phosphatase 1C catalytic subunit

P36873_HUMAN