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Anti-ABCB5 antibody Europäischer Partner

ArtNr STJ96976-50
Hersteller St John's Laboratory
Menge 50ul
Kategorie
Typ Antibody Monoclonal
Applikationen WB, IF, IHC-P
Clon 11A2
Specific against Human
Host Mouse
Isotype IgG1
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Anti-Atp-Binding Cassette Sub-Family B Member 5 antibody</br>Anti-Abcb5 P-Gp antibody</br>Anti-P-Glycoprotein Abcb5 antibody</br>Anti-ABCB5 antibody
Similar products Anti-Atp-Binding Cassette Sub-Family B Member 5 antibody
Anti-Abcb5 P-Gp antibody
Anti-P-Glycoprotein Abcb5 antibody
Anti-ABCB5 antibody
Lieferbar
Clonality
Monoclonal
Conjugation
Unconjugated
Formulation
PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide and 50% Glycerol.
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Uniprot ID
Q2M3G0
Storage
Store at-20° C, and avoid repeat freeze-thaw cycles.
Description
ABCB5 is a protein encoded by the ABCB5 gene which is approximately 138, 6 kDa. ABCB5 is localised to the cell membrane. It is involved in CDK-mediated phosphorylation, the removal of Cdc6 and the transport of glucose, bile salts, metal ions and amine compounds. This protein falls under the ATP-binding cassette transporter superfamily of integral membrane proteins. It participates in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules. ABCB5 is expressed in the skin. Mutations in the ABCB5 gene may result in malignant conjunctival melanoma. STJ96976 was developed from clone 11A2 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous ABCB5 proteins.
Gene ID
Gene symbol
Immunogen
Synthetic Peptide
Short Description
Mouse monoclonal against ABCB5
Tissue specificity
Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.
Cellular localization
Cell Membrane
Multi-Pass Membrane Protein
Dilution range
WB 1:2000
IF 1:200
IHC 1:50-300
Alternative names
Anti-Atp-Binding Cassette Sub-Family B Member 5 antibody
Anti-Abcb5 P-Gp antibody
Anti-P-Glycoprotein Abcb5 antibody
Anti-ABCB5 antibody
Protein name
Atp-Binding Cassette Sub-Family B Member 5
Abcb5 P-Gp
P-Glycoprotein Abcb5
Note
FOR RESEARCH USE ONLY (RUO).
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50ul
Lieferbar: In stock
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